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M9640803.TXT
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1996-03-04
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Document 0803
DOCN M9640803
TI Human papillomavirus infection and associated disease in persons
infected with human immunodeficiency virus.
DT 9604
AU Vernon SD; Holmes KK; Reeves WC; Division of Viral and Rickettsial
Diseases, Centers for Disease; Control and Prevention, Atlanta, Georgia
30333, USA.
SO Clin Infect Dis. 1995 Aug;21 Suppl 1:S121-4. Unique Identifier :
AIDSLINE MED/96002840
AB Genital infection with human papillomavirus (HPV) is the most common
sexually transmitted infection in the United States. Genital or anal
infection with oncogenic types of HPV, particularly types 16 and 18, can
cause precancerous lesions of the squamous epithelium. Infection with
human immunodeficiency virus (HIV) increases the risk for HPV-associated
genital neoplasias in both women and men. Detectable cervical and anal
HPV infection is more prevalent among women and men with HIV infection
than among those who are HIV-seronegative, and the magnitude of the
increase in prevalence is proportionate to the severity of
immunosuppression. Coinfection with HIV and HPV increases the risk for
genital intraepithelial neoplasia, and the increase in this risk also
reflects the severity of immunosuppression. One difficulty complicating
elucidation of the association between HIV and HPV infections is that
the risk factors for acquisition and transmission of the two viruses are
similar. The strength of this association represents a burgeoning health
problem, yet there are no treatment guidelines aimed specifically at
HIV-infected individuals with HPV-associated genital neoplasias.
Treatment of HPV-associated cervical disease in HIV-infected women may
be further complicated by a greater risk of treatment failure and
recurrence than exists among HIV-seronegative women; it is not known
whether dysplasia progresses to invasive disease more rapidly in women
infected with HIV. A thorough understanding of the associations among
HIV, HPV, and HPV-associated disease is essential to the development of
effective strategies for intervention and prevention.
DE Female Genital Diseases, Female/*EPIDEMIOLOGY/PREVENTION & CONTROL
Genital Diseases, Male/*EPIDEMIOLOGY/PREVENTION & CONTROL Human HIV
Infections/*COMPLICATIONS Incidence Male *Papillomavirus, Human
Papovaviridae Infections/*EPIDEMIOLOGY/PREVENTION & CONTROL/
TRANSMISSION Risk Factors Sexually Transmitted Diseases,
Viral/*EPIDEMIOLOGY/PREVENTION & CONTROL/TRANSMISSION Tumor Virus
Infections/*EPIDEMIOLOGY/PREVENTION & CONTROL/ TRANSMISSION United
States/EPIDEMIOLOGY JOURNAL ARTICLE REVIEW REVIEW, TUTORIAL
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).